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33rd Camerino-Cyprus Symposium

Camerino, May 15-19, 2016

Receptor Chemistry: Reality and Vision

 

  Sunday 15th 2016

Palazzo Ducale - Aula Arangio Ruiz

 
18.30-18.45

Opening

 
18.45-19.45 "Seven Transmembrane Receptors"
Robert J. Lefkowitz
2012 Nobel Prize in Chemisty
(Duke University Medical Center - USA)
Abstract
20.00 Medieval Dinner (Hotel "I Duchi")  

Program

 

Monday 16th 2016

Palazzo Ducale - Aula Arangio Ruiz

 
9.00-9.10

Session Title: "Modeling GPCRs in the Structural Biology Era"
Chairs:
Stefano Costanzi (American University - USA)

Abstract

9.10-9.40

"Homology Modeling of a Class A GPCR in the Inactive Conformation: a Quantitative Analysis of the Correlation Between Model/Template Sequence Identity and Model Accuracy"
Stefano Costanzi

(American University - USA)

NEW
9.40-10.10

“Structural Insights into Transmembrane Receptor Signaling”
Andrew C. Kruse
(Harvard Medical School, Boston, MA - USA)

Abstract
10.10-10.30

Coffee Break

 
10.30-11.00

"Revelations from GPCR Protein-Ligand Structures, with Key Roles for Water and the Prediction of Kinetics."
Jonathan S. Mason
(Heptares, Welwyn Garden City, UK)

Abstract
11.00-11.30

"Structural Basis for G-Protein Selectivity Using Multiscale Dynamics and FRET Sensors"
Nagarajan Vaidehi
(City of Hope Duarte, CA, USA)

Abstract
11.30-12.00

"Modelling the Cannabinoid 2 Receptor and Structure Based Studies of Agonist/Antagonist Molecular Switches"
Claudio Cavasotto

(IBioBA-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina)

Abstract
12.30

Lunch (Hotel "I Duchi")

 
15.00-15.10

Session Title: "Modeling GPCRs in the Structural Biology Era"
Chairs:
Stefano Moro (University of Padua - Italy)

Abstract
15.10-15.40

"Polypharmacology of Conformationally Rigid Nucleosides: Purine Receptors and Beyond”
Kenneth A. Jacobson
(NIDDK - NIH - Bethesda - USA)

Abstract
15.40-16.10

"Molecular Modelling Studies on Adenosine Receptors and Their Ligands"
Diego Dal Ben
(University of Camerino - Italy)

Abstract
16.10-16.40

"Mutant Muscarinic Receptors as Novel Chemogenetic Tools" 
Jurgen Wess
(NIDDK - NIH - Bethesda, MD, USA)

Abstract

16.40-17.00

Coffee Break

 
17.15-18.15

Conferment of "Laurea Honoris causa" to
Dr. Robert J. Lefkowitz

Palazzo Ducale - Aula della Muta
 

 
18.15-19.00 Concert: "Coro Universitario Camerte"  
20.00

Vegan Dinner (Hotel "I Duchi")

 
 

Tuesday 17th 2016

Palazzo Ducale - Aula Arangio Ruiz

 
9.00-9.10

Session Title: "Understanding GPCR-Ligand Interactions"
Chair:
R
ob Leurs  (VU University Amsterdam, the Netherlands)

Abstract
9.10-9.40

"Identification of Endogenous and Surrogate Ligands for Orphan G Protein-Coupled Receptors"
David E. Gloriam
(Univerisity of Copenhagen, Denmark)

Abstract
9.40-10.10

"Structural Biology of the EDG Receptors"
 Mike A. Hanson
(GPCR consortium, USA)

Abstract
10.10-10.30

Coffee Break

 
10.30-11.00

"GPCR Ligand Binding Kinetics: from X-Ray Structure to Understanding of  Antagonist Dissociation Kinetics"
Chris de Graaf
(VU University Amsterdam, the Netherlands)

Abstract
11.00-11.30

"Fragment Llinking for GPCRs: a Case Study on Dopamine D3 Receptors"
Gyorgy M. Keseru
(Hungarian Academy of Science, Hungary)

Abstract
11.30-12.00

"Revisiting Mechanism of Action and Clinical Profile of Choline Alphoscerate.
An Experience in the Field of Cognitive Dysfunctions"
Francesco
Amenta
(University of Camerino, Italy)

Abstract
12.30

Lunch (Hotel "I Duchi")

 
15.00-15.10


Session in memory of Dr. Wolfgang Froestl

Session Title: "Advanced Clinical Studies with Drugs for the Treatment of Alzheimer’s and Parkinson’s Disease"
Chair:  David A. Lowe
(AC Immune SA - Switzerland)

Abstract
15.10-15.40

"Tozadenant, a Potent and Selective Adenosine A2A Receptor Antagonist "
Stephen I Bandak
(Biotie Therapies Inc. - USA)

Abstract
15.40-16.10

"ANAVEX-2-73, a Sigma-1 Receptor Agonist"
Christopher U. Missling
(ANAVEX Life Science Corp. - USA)

 
16.10-16.40

"Azeliragon; A RAGE Antagonist in Phase 3 Clinical Trials for the Treatment of Alzheimer’s Disease"
Robert C. Andrews
(vTv Therapeutics - USA)

 
16.45

Tour to Tolentino: visit to "International Museum of Humor in Art"
and
Chapel of Saint Nicholas

 
20.00

Dinner and Music @ Area T - Tolentino

 
 

Wednesday 18th 2016

Palazzo Ducale - Aula Arangio Ruiz

 
9.00-9.10

Session Title: "Dopamine D2-like Receptors: From Structure and Function to Potential Therapeutics"
Chair:
 Amy H. Newman (NIDA-IRP, NIH - USA)

Abstract
9.10-9.40

"D2-Like Receptors as the Base of Multi-Target Directed Ligands for the Treatment of Schizophrenia"
Stefania Butini
(University of Siena - Italy)

Abstract
9.40-10.10

"Novel Bitopic Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine  D2 Receptor (D2R) Biased Agonism"
Alessandro Bonifazi
(NIDA-IRP, NIH- USA)

Abstract
10.10-10.30

Coffee Break

 
10.30-11.00

"Implication of Multifunctional D3 Preferring Agonist as Therapeutic Agents in Parkinson’s Disease"
Aloke Dutta
(Wayne State University - USA)

Abstract
11.00-11.30

"VK4-116 - A Novel and Highly Selective Dopamine D3 Receptor Antagonist That Attenuates Oxycodone and THC Self-Administration"
Amy H. Newman
(NIDA-IRP, NIH- USA)

Abstract
11.30-12.15

Poster Session

 
12.30

Lunch (Hotel "I Duchi")

 
15.00-15.10

Session Title: "Beyond Receptor Chemistry: Transporters"
Chair:
Richard A. Glennon
  (Virginia Commonwealth University - USA)

Abstract
15.10-15.40

"Transporters as Clinical Targets of Drugs: Amphetamines, New Psychoactive Substances and the Monoamine Transporter Cycle”
Harald H. Sitte
(Medical University Vienna - Austria)

Abstract
15.40-16.10

"Direct Assessment of Conformational Changes Uncovers Functional
Regulation by K+ in a  Neurotransmitter: Sodium Symporter"
Claus Juul Løland
(University of Copenhagen - Denmark)

Abstract
16.10-16.30

Coffee Break

 
16.30-17.00

"Beyond Monoamine Transporters: Organic Cation Transporters (OCTs)"
Malgorzata Dukat
(Virginia Commonwealth University - USA)

Abstract
17.00-17.30

"Synthetic Cathinones: a New Class of Abused Substances and their Actions at Monoamine Transporters"
Richard A. Glennon
(Virginia Commonwealth University - USA)

Abstract
17.30-18.30

"Remembering Maria Pigini and Her Two Decades of Imidazolines"
Fabio del Bello - Carla Ghelardini - Antonio Carrieri

 
18.30-19.00

Maria "Nelly" Pigini Awards

 
20.00

Dinner  (Hotel "I Duchi") & Musical entertainment by Filarmonici Camerti (Palazzo della Musica)

 
 

Thursday 19th 2016

Palazzo Ducale - Aula Arangio Ruiz

 
9.00-9.10

Session Title: "The Future"
Chair:
David J. Triggle (SUNY University - USA)

Abstract
9.10-9.40

"Publish and Perish: Where Is Scientific Publication Going?"
Chris R. Triggle
(Weill Cornell Medical College in Qatar - Qatar)

Abstract
9.40-10.10

"Drug Discovery Innovation: The Evolving Role of Medicinal Chemistry"
Joel C. Barrish
(Achillion Pharmaceuticals, Inc. - USA)

Abstract
10.10-10.30

Coffee Break

 
10.30-11.00

"What Can We Get from Natural Products and Alternative Medicine?"
Shyam S. Chatterjee
(Germany)

Abstract

11.00-11.30

"Zombies and Their Pharmacology. What Can Host-Parasite Relationships Teach us About New Pharmacological Approaches?"
David J. Triggle
(SUNY University - USA)

Abstract

11.30-12.00

"Summing Up"
Richard A. Glennon  (Virginia Commonwealth University - USA)

 

12.30

Social Tour to Ascoli Piceno and Social Dinner

 

 

 

 

Info: secretariat.camerino@unicam.it